NAD+ Nasal Spray
Compounded NAD+ delivered intranasally — a needle-free daily protocol that restores the cellular coenzyme behind energy production, cognitive performance, and longevity signaling. No injections. No compromise.
Starting at
$189 / month
Billed as $567 every 90 days · 90-day supply shipped at enrollment
Physician consultation included · Renewed every 90 days
You must be evaluated by a physician to receive a prescription. Consult fee applies whether or not you are a candidate.
NAD+ by a Different Route
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential to every cell in your body — governing energy metabolism, DNA repair, and the activation of sirtuins, the proteins most directly linked to biological aging. NAD+ levels fall dramatically after 40, and restoring them is one of the most targeted interventions available in longevity medicine.
The nasal route delivers NAD+ through the highly vascularized nasal mucosa directly into systemic circulation — bypassing the digestive tract entirely. Uniquely among NAD+ delivery methods, the intranasal route also provides potential access to the central nervous system via the olfactory bulb pathway, which may explain why many patients report particularly pronounced cognitive effects.
The result: a convenient, needle-free daily protocol that supports cellular energy, mental clarity, and longevity pathways — without the injection routine.
Benefits of Intranasal NAD+
The nasal delivery route is prized for its convenience and the unique potential for enhanced brain delivery — making it a favorite for patients focused on cognitive performance alongside longevity.
Cognitive Performance
The olfactory pathway may allow intranasal NAD+ to reach the brain more directly than other delivery routes. Patients report improved focus, faster mental processing, and reduced brain fog — often noticed within the first 1–2 weeks.
Cellular Energy
NAD+ fuels mitochondrial ATP production — the engine behind every cellular function. Restoring NAD+ levels improves how efficiently your cells generate and use energy, reducing fatigue and improving physical and mental stamina.
Mood & Sleep
NAD+ is a cofactor in the synthesis of serotonin and other neurotransmitters. Many patients on intranasal NAD+ report improved mood stability, reduced afternoon energy crashes, and more restorative sleep quality over time.
Longevity Pathways
NAD+ activates sirtuins — proteins that regulate cellular stress responses, genomic stability, and inflammation. Sustained sirtuin activation is one of the most researched mechanisms in longevity science, linked to cellular protection and healthspan extension.
Nasal Spray vs. Injectable
Both are physician-prescribed, compounded NAD+ — the difference is delivery method, dose concentration, and protocol preference.
Nasal Spray — Best For
- Needle-averse patients — no injections ever
- Primary focus on cognitive clarity and mental performance
- Daily convenience — no refrigeration, no reconstitution
- Lower entry price — starting at $189/mo
Injectable — Best For
- Maximum systemic NAD+ restoration — highest plasma levels
- Athletic performance, body composition, and recovery focus
- Pairing with other injectable therapies (sermorelin, GLP-1)
- Patients comfortable with self-injection protocols
Your physician will help determine which format — or combination — is right for your goals and lifestyle.
A Spray. Once a Day. Done.
NAD+ nasal spray integrates into your morning routine in seconds. No needles, no preparation, no refrigeration required. Simply spray, and you're done — the most friction-free longevity protocol available.
- 1–2 sprays per nostril, once to twice daily — per physician protocol
- Each spray delivers a precise dose of compounded NAD+
- No needles, no reconstitution, no cold-chain storage required
- Room temperature stable for the duration of the monthly supply
- Absorbs rapidly through nasal mucosa — results felt by most within minutes
- Subtle, non-irritating — designed for daily long-term use
Full administration instructions and dosing protocol are included with every shipment. Your physician is available throughout your treatment for any questions.
Eligibility Criteria
NAD+ nasal spray is generally well-tolerated across a wide range of adults seeking longevity support and cognitive optimization. Final eligibility is always determined by your physician after reviewing your health profile.
- Adults 30+ seeking cellular energy restoration and cognitive support
- Patients preferring a needle-free NAD+ protocol
- High performers, executives, and creatives prioritizing mental performance
- Patients on GLP-1 or peptide therapy seeking cognitive complement
- No active nasal polyps, nasal surgery within 60 days, or chronic sinusitis
- Not pregnant or breastfeeding
What You Pay. Nothing Hidden.
Private pay means no insurance games, no surprise bills. Your cost is determined by your physician-prescribed dose.
Starting Protocol
$150/mo
Once daily protocol, standard concentration
- Physician review included
- Prescription + dispensing
- Discreet shipping to your door
Therapeutic Protocol
$210/mo
Twice daily protocol, higher concentration (per physician guidance)
- Everything in starting tier
- Higher dose / twice-daily bottle
- Physician-guided dose titration
Grace Care Plan
Included
Optional — opt out anytime with 30-day notice
- 90-day physician check-ins
- Automatic 90-day refill
- Ongoing dose adjustments
Consultation fee applies whether or not you are determined to be a candidate. Pricing is subject to physician-prescribed dose. No insurance accepted.
Takes under 10 minutes. No commitment required.
NAD+ Nasal Spray FAQ
How much does NAD+ nasal spray cost at Grace Longevity?
NAD+ nasal spray therapy $189/mo, billed as $567 every 90 days for a 90-day supply. Physician consultation, prescription, and pharmacy dispensing are all included. Your physician reviews your progress and renews your prescription at every 90-day cycle. A consultation fee applies whether or not you are ultimately determined to be a candidate.
How does nasal spray compare to injectable NAD+?
Both deliver physician-prescribed, compounded NAD+ — the difference is the route. Injectable achieves higher systemic plasma concentrations and is preferred for patients focused on body composition, recovery, and total cellular restoration. Nasal spray is needle-free, more convenient for daily use, and may offer enhanced brain delivery via the olfactory pathway — making it a standout choice for cognitive performance and mood support.
How quickly will I feel the effects?
Many patients report a noticeable lift in mental energy and clarity within the first few days of intranasal NAD+ use. The faster onset versus injectable is a commonly reported observation — though individual response varies. Sustained benefits build over weeks of consistent use.
Can I combine nasal spray with other Grace Longevity therapies?
Yes — NAD+ nasal spray is frequently combined with GLP-1 therapies (semaglutide, tirzepatide) and sermorelin. Many patients on GLP-1 therapy find the cognitive and energy benefits of NAD+ an ideal complement to the metabolic and weight loss benefits of GLP-1. Your physician will review your complete protocol.
Does it require refrigeration?
No. Unlike injectable NAD+, the nasal spray formulation is stable at room temperature for the duration of your 90-day supply. No cold packs, no refrigerator space required — store it on your countertop or medicine cabinet.
How quickly will I receive my medication?
After physician approval, your prescription is sent directly to a licensed compounding pharmacy and shipped to your door. Most patients receive their medication within 3–5 business days of approval.
One Assessment Away from Starting
Our intake takes under 10 minutes. A physician will review your profile and determine if NAD+ nasal spray is right for you.
Begin My AssessmentConsultation fee applies regardless of candidacy outcome.