Sermorelin
Compounded sermorelin — a physician-prescribed GHRH analog that stimulates your body's own natural growth hormone production, without synthetic hormone replacement.
Starting at
$259 / month
Billed as $777 every 90 days · 90-day supply shipped at enrollment
Physician consultation included · Renewed every 90 days
You must be evaluated by a physician to receive a prescription. Consult fee applies whether or not you are a candidate.
What is Sermorelin?
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) — the 29-amino-acid peptide your hypothalamus produces naturally to signal your pituitary gland to release growth hormone (GH).
As we age, natural GHRH production declines and growth hormone levels fall — contributing to decreased muscle mass, increased body fat, reduced energy, impaired sleep quality, and accelerated skin aging. Sermorelin restores the upstream signal, prompting your pituitary to produce and release GH naturally.
Unlike direct growth hormone injections, sermorelin works within your body's own feedback loops — preserving the natural somatostatin braking mechanism that prevents excess GH. The result is a physiologically balanced restoration of GH levels, not a pharmacological override.
The Benefits of Optimized GH
Growth hormone is involved in virtually every system of the body. Restoring optimal levels produces changes patients notice across multiple dimensions of health.
Sleep Quality
Deeper, more restorative sleep. GH is primarily released during slow-wave sleep — optimizing GH levels reinforces this cycle, with most patients reporting improved sleep within the first 3–4 weeks.
Energy & Vitality
Reduced fatigue and sustained daytime energy. Patients consistently report feeling more alert, motivated, and mentally sharp as GH levels normalize over the first 4–8 weeks of therapy.
Body Composition
Increased lean muscle mass and reduced visceral fat. GH is a primary driver of lipolysis (fat breakdown) and protein synthesis — making body recomposition more achievable with consistent effort.
Skin & Recovery
Improved skin elasticity, texture, and hydration. Enhanced tissue repair and faster recovery from exercise. Many patients describe visible skin quality improvements by months 3–4 of consistent therapy.
Your First 90 Days
Foundation
200–300 mcg nightly injection before bed. Most patients notice improved sleep depth and quality within the first 2–3 weeks. Your body begins restoring its natural GH rhythm.
Optimization
Dose adjusted by your physician based on IGF-1 response. Energy improvements and early body composition shifts become more apparent. Sleep quality continues to improve.
Transformation
The full clinical picture emerges. Lean mass gains, fat reduction, improved skin quality, and sustained energy become measurable. This is the benchmark window for evaluating full response.
Simple. Nightly. At Home.
Sermorelin is administered as a small subcutaneous injection — similar to an insulin injection — into the fatty tissue of the abdomen or thigh. Most patients describe it as nearly painless and the routine becomes second nature within days.
- Administered nightly before bed — aligns with natural GH pulse
- 200–500 mcg dose, adjusted to your physician's protocol
- Insulin syringe (29–31 gauge) — minimal discomfort
- Rotate injection sites to prevent tissue irritation
- Medication arrives lyophilized (freeze-dried) — reconstitute with bacteriostatic water included
- Store refrigerated at 36–46°F after reconstitution
Full reconstitution instructions, injection guidance, and storage protocol are included with every shipment. Your physician is available throughout your treatment for any questions.
Eligibility Criteria
Sermorelin is generally indicated for adults experiencing symptoms of age-related growth hormone decline. Final eligibility is always determined by your physician after reviewing your health profile.
- Adults 30+ experiencing age-related GH decline
- Symptoms of low GH: fatigue, poor sleep, reduced muscle mass, increased body fat, reduced recovery
- Not currently using synthetic growth hormone (HGH)
- No history of active cancer or pituitary tumors
- Not pregnant or breastfeeding
- No untreated hypothyroidism (thyroid function should be optimized prior to therapy)
What You Pay. Nothing Hidden.
Private pay means no insurance games, no surprise bills. Your cost is determined by your physician-prescribed dose.
Starting Dose
$259/mo
Billed as $777 every 90 days · Physician consult included
200–300 mcg nightly
- Physician review included
- Prescription + dispensing
- Discreet cold-chain shipping
Therapeutic Dose
$189–259/mo
300–500 mcg nightly (per physician guidance)
- Everything in starting tier
- Higher dose vial dispensed
- Physician-guided dose escalation
Grace Care Plan
Included
Optional — opt out anytime with 30-day notice
- 90-day physician check-ins
- Automatic 90-day refill
- Ongoing dose adjustments
Consultation fee applies whether or not you are determined to be a candidate. Pricing is subject to physician-prescribed dose. No insurance accepted.
Takes under 10 minutes. No commitment required.
What the Data Shows
From peer-reviewed clinical research on sermorelin and GHRH analog therapy in adults.
35–50%
IGF-1 Elevation
Mean increase in adults with GH deficiency
16 wks
Meaningful Response Time
Randomized adult trial benchmark
Natural
GH Feedback Preserved
Unlike direct HGH injection
503A
Legal Compounding Status
FDA-approved bulk substance list
Results are from peer-reviewed clinical research and represent population averages. Individual results vary based on dose, adherence, baseline GH levels, lifestyle, and individual metabolic factors. This information is not a guarantee of outcome. IGF-1 data sourced from adult GHRH analog research (1992–2008).
Sermorelin FAQ
How much does sermorelin cost at Grace Longevity?
Sermorelin therapy $259/mo, billed as $777 every 90 days for a 90-day supply. Physician consultation, prescription, and pharmacy dispensing are all included. Your physician reviews your progress and renews your prescription at every 90-day cycle. A consultation fee applies whether or not you are ultimately determined to be a candidate.
How is sermorelin different from human growth hormone (HGH)?
HGH therapy involves injecting synthetic growth hormone directly — which suppresses your pituitary's natural GH production over time. Sermorelin works upstream, stimulating your pituitary to produce its own GH naturally. This preserves the body's feedback regulation (somatostatin braking), making it a more physiologically balanced approach with a well-established safety profile.
How is sermorelin administered?
Sermorelin is injected subcutaneously (under the skin) nightly before bed, using a small insulin-style syringe. Most patients find the routine simple and nearly painless. Full reconstitution and injection instructions are included with every shipment.
How long until I see results?
Most patients notice improved sleep quality within the first 2–4 weeks. Meaningful energy and body composition improvements typically emerge between months 2 and 4. A 3–6 month minimum is recommended to fully evaluate your clinical response.
Can I take sermorelin alongside semaglutide or tirzepatide?
Many patients use sermorelin alongside GLP-1 therapy. The combination can be especially beneficial for body recomposition — GLP-1s drive fat loss while sermorelin supports lean muscle preservation. Your physician will review your full health profile and prescriptions to determine what is appropriate for you.
How quickly will I receive my medication?
After physician approval, your prescription is sent directly to a licensed compounding pharmacy and shipped to your door. Most patients receive their medication within 3–5 business days of approval.
One Assessment Away from Starting
Our intake takes under 10 minutes. A physician will review your profile and determine if sermorelin is right for you.
Begin My AssessmentConsultation fee applies regardless of candidacy outcome.